Which statement about nitroglycerin interactions is accurate?

Which statement about nitroglycerin interactions is accurate?

• A. Viagra within 24 hours; Cialis/Levitra within 48 hours
• B. No interactions with erectile dysfunction medications
• C. ED meds require a higher dose of nitroglycerin
• D. Nitroglycerin neutralizes ED meds

Answer: (A)

Nitroglycerin and erectile dysfunction medications (PDE5 inhibitors) both lower blood pressure. When used together, they can cause a dangerous, sometimes life‑threatening drop in blood pressure, so nitroglycerin must be avoided for a certain period after taking an ED med. The safe-window guidance is that sildenafil (Viagra) should have a 24-hour clearance before nitroglycerin, while tadalafil (Cialis) or vardenafil (Levitra) require about 48 hours. This makes the described timing the best choice because it reflects how long each ED medication can still potentiate nitroglycerin’s vasodilatory effect. The other statements aren’t accurate because ED meds and nitroglycerin do interact, there isn’t a need to increase the nitroglycerin dose, and nitroglycerin does not neutralize ED meds.

Nitroglycerin and erectile dysfunction medications (PDE5 inhibitors) both lower blood pressure. When used together, they can cause a dangerous, sometimes life‑threatening drop in blood pressure, so nitroglycerin must be avoided for a certain period after taking an ED med. The safe-window guidance is that sildenafil (Viagra) should have a 24-hour clearance before nitroglycerin, while tadalafil (Cialis) or vardenafil (Levitra) require about 48 hours. This makes the described timing the best choice because it reflects how long each ED medication can still potentiate nitroglycerin’s vasodilatory effect. The other statements aren’t accurate because ED meds and nitroglycerin do interact, there isn’t a need to increase the nitroglycerin dose, and nitroglycerin does not neutralize ED meds.